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If you are taking oral progestogen as part of your HRT (for example Utrogestan, Norethisterone, Medroxyprogesterone), then you need to be aware that tirzepatide (Mounjaro) may have an impact on the effectiveness of your HRT

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K., and Sanlioglu S., Incretins: Their Physiology and Application in the Treatment of Diabetes Mellitus, Diabetes/Metabolism Research and Reviews 30 (2014): 354371

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To enhance the safety of GLP-1-RAs in clinical practice, it is critical to carefully select patients and adequately manage gastrointestinal side effects, despite the medications' typically excellent tolerance [80]

The idea of microdosing GLP-1s (glucagon-like peptide-1 receptor agonists) has bubbled into the public consciousness