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Description
Other health conditions may also make some people less likely to see significant weight loss on GLP-1s

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GLP-1R works through the combination of the endogenous ligand Glucagon-like peptide-1 (GLP-1) or exogenous agonists, which activate multiple intracellular signaling pathways that enhance insulin secretion, inhibit glucagon secretion, protect -cells from apoptosis, delay gastric emptying and increase satiety

[DOI] [PMC free article] [PubMed] [Google Scholar] 104.Rentzeperi E., Pegiou S., Koufakis T., Grammatiki M., Kotsa K

For persistent cases, osmotic laxatives like MiraLAX are generally considered safe to use alongside GLP-1 protocols
Patients who do not see progress early in treatment often become frustrated and disengage
