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Together with dihydrobiopterin (BH2), BH4 forms a redox cycle that scavenges endogenous oxidative free radicals, thereby suppressing ferroptosis ( + /NAD(P)H as a cofactor ( De novo synthesis of BH4 depends on three enzymes: GCH1, 6-pyruvoyltetrahydropterin synthase (PTS), and sepiapterin reductase (SPR)

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In addition, GLP-1 analogs lead to improvements in brain glucose metabolism and glucose transport across the bloodbrain barrier in Alzheimers disease

for instance, pioglitazone has fallen into disuse