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In this issue of the JCI , Farokhnia and colleagues used a reverse translational approach to examine the effects of enhancing GLP-1R activity either through synthetic agonists or inhibition of its degrading enzyme, dipeptidyl peptidase-4 (DPP-4) on alcohol consumption in both humans and preclinical models (Figure 1) (4)

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33 Similar findings were observed in a meta-analysis of 40 trials which concluded that GLP-1RAs were highly effective at lowering circulating glucose levels without causing hypoglycemia

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BMJ Open 2018;8:e020961