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The FDA approved saxagliptin, linagliptin, and alogliptin, and the European Union and Japan approved vildagliptin, anagliptin, teneligliptin, trelagliptin, and omarigliptin

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Pharmacokinetic studies have shown reduced exposure to ethinyl estradiol and progestins after tirzepatide initiation, with the greatest effect occurring after initial doses and dose escalations

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Nauck et al, 2021)