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By simultaneously activating the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors, it effectively promotes insulin secretion and reduces glucagon release, leading to better blood sugar regulation and weight loss support

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In this context, our data with nifedipine can be understood

The landscape of heart failure (HF) management is evolving alongside a deeper understanding of how metabolic dysfunction drives cardiac pathology and the progression of HF, particularly in phenotypes like HF with preserved ejection fraction (HFpEF) associated with obesity

Moreover, Cotadutide was demonstrated to decrease fat accumulation in the liver and retard hepatic fibrogenesis developing in high-fat diet (HFD) and HFD/CCl4 mouse models (138, 139)

References Wilding, J