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What do GLP-1s actually do in the gut

There may be obstruction of small airways leading to chronic obstructive bronchitis and destruction of the alveolar walls, known as emphysema, resulting in air trapping, dyspnea, and diminished physical capacity

Nonetheless, this classical view has been challenged by the development of thiazolidinediones, which possess potent insulin-sensitizing properties despite having very low to absent PPAR-binding affinity 51

OR: 0.80

No pharmacological evidence currently supports a direct anti-inflammatory or sebum-regulating effect of GLP-1 agonists on the pilosebaceous unitthe primary site of acne pathology

266,267 Nervous System GLP-1 has also been reported to affect the nervous system