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Inflammation is a common cause of skin sensitivity, resulting in symptoms like redness, itching, and rashes

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As diabetes is a major risk factor for CKD [67], specialized expert groups such as the Kidney Disease: Improving Global Outcomes (KDIGO) team, with the endorsement of both ADA and EASD, recommend that glycemic management for T2D patients with CKD should involve a combination of metformin and a SGLT-2 inhibitor as first-line therapy, with other drugs such as SUs considered only when additional therapies are needed for optimum glycemic control [68]

GLP-1RA can also affect the process of skin aging through interaction with advanced glycation end products (AGEs) and RAGE (receptors of AGEs) activation

doi: 10.1210/er.2015-1104 147 Martnez-GarcaMMoncayoSInsenserMlvarez-BlascoFLuque-RamrezMEscobar-MorrealeHF
