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The median effective dose (ED 50 ) of Ex-4c for the suppression of food intake was obtained by plotting normalized food intake at 6 hours since refeeding on the Y-axis versus the common logarithm of Ex-4c dose (g) on the X-axis, and performing curve fitting using the equation shown below: where Hill=Hill slope, Max=maximum asymptote, and Min=minimum asymptote

Additionally, lower levels of glutathione and total antioxidant capacity were observed in PCOS women [54]

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GLP-1 evolved to exert rapid transient effects to blunt postprandial glucose excursions, with a plasma half-life of a few minutes 3234 , and is highly susceptible to enzymatic degradation 3537

Mechanism of Action IGF-1 LR3 binds to insulin-like growth factor-1 receptors on the cell surface, activating intracellular signaling pathways that regulate cell proliferation, survival, and metabolism