what to expect on tirzepatide Expect: Weight Loss in the First Week What to Know Before Starting

However, persistent severe nausea after week 4, nausea accompanied by vomiting, or signs of dehydration (dark urine, dizziness, extreme weakness) warrant immediate contact with your prescribing provider

Some patients report receiving a brief telehealth consultation

Most patients experience a reduction in appetite, improved blood sugar regulation, and steady, sustainable weight loss

Meghan Garcia-Webb, MD, obesity medicine doctor at Weight Medicine MD, told Healthline its not uncommon for people to have significant side effects from one GLP-1 medication but not another

Seek professional advice and treatment from dermatologists for breakouts

Jones DW, Ferdinand KC, Taler SJ et al (2025) 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines