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I would not recommend microdosing GLP-1s for individuals with significant amounts of weight to lose or known metabolic dysregulation. The bottom line is that there are still questions regarding the effectiveness and safety of microdosing GLP-1 medications, and this type of regimen is not for everyone

If you take insulin for type 2 diabetes, your provider will pay close attention to your current regimen and may recommend insulin dose adjustments when starting a GLP-1 medication to prevent hypoglycemia

One company is Zealand Pharma, which presented mid-stage data from a drug called petrelintide that it's developing with Roche

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Rybelsus is an oral GLP-1 receptor agonist that enhances glucose-dependent insulin secretion, suppresses glucagon, and slows gastric emptying to improve glycaemic control in type 2 diabetes

These medications mimic the hormone glucagon-like peptide-1, which helps regulate blood sugar and appetite