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He is a division chair of supply chain management at Mayo Clinic

Table of Contents Key Takeaways Metformin is a cheaper option than GLP-1 drugs

"When I talk to patients about weight management, I always bring up these other options as well, because some people don't want to use a needle." Older prescription weight loss pills include: Hydrogel ( Plenity ) Naltrexone-bupropion ( Contrave ) Orlistat ( Xenical ) Phentermine (Adipex, Suprenza) Phentermine topiramate (Qsmyia) While the GLP-1 agonists can produce a weight loss of 10% to 20%, the average weight lost with older medications is lower in the range of 5% to 10% of the starting body weight

Shigeto M, Ramracheya R, Tarasov AI et al (2015) GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation

48,109-111 The diagnosis of diabetic diarrhoea is essentially clinical and one of exclusion

Physiological function of glucagon-like peptide-1 (GLP-1)
