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This is the most important unknown in the current data

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This can result in sarcopenic obesity , particularly in older or frail populations, and raises new questions about treatment sustainability

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These experiments support the notion that MK-801 does not enhance the pharmacokinetics of gut peptides and that the additional metabolic benefits and synergistic weight loss effects brought about by MK-801 are dependent on NMDA receptor antagonism in GLP-1-receptor-positive neurons

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Drug Discov Today (2013) 18(23-24):117384

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