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The initial muscle loss seen with GLP-1 RA treatment as well as the ongoing replacement of muscle with fat with treatment cycles involving treatment interruptions can result in unfavorable changes in body composition in patients with obesity that can have profoundly negative repercussions, and can exacerbate obesity-related metabolic and health concerns 14,15,16

Studies show that people who stop taking the medication may regain the weight theyve lost

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The "canary in the coal mine" metaphor lands hardweight trajectory as early warning system for multisystem decline, not just a nutritional footnote
