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Alexiades M, Palm MD, Kaufman-Janette J, et al

L., Siegelaar, S

GLP-1 is released in response to food intake

Lack of sleep is known to increase hunger hormones (like ghrelin) and decrease satiety hormones, like leptin, which can cause users to overeat, undermining how GLP-1s suppress appetite

The Canadian Journal of Anesthesia conducted a gastric emptying study, documenting that slower gastric emptying led to pulmonary aspiration during general anesthesia or deep sedation

Considerations Gaps between trial successes and real-world outcomes remain, especially for GLP-1 nonresponders that often face more considerable barriers to weight loss success
