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Interestingly, tirzepatide also markedly reduced body weight in patients with type 2 diabetes, which led to studies on its efficacy for the treatment of obesity in the absence of type 2 diabetes

How GLP-1 Medications Work for Weight Loss GLP-1 medications work by targeting specific areas in the brain that regulate appetite and digestion

Researchers have also noted that 70% of diabetes patients discontinue GLP-1 receptor agonist treatment within two years, limiting the long-term efficacy of these drugs

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Rapid weight loss can lead to a temporary spike in the waste product uric acid created when the body breaks down chemicals called purines in food and drinks that raises the risk of gout, he said