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In expanded populations, comparing semaglutide versus sitagliptin for the composite outcome of myocardial infarction or stroke yielded a hazard ratio of 0.82 (95% confidence interval (CI) 0.74 to 0.91), and comparing tirzepatide versus dulaglutide for the composite outcome including mortality yielded a hazard ratio of 0.87 (95% CI 0.75 to 1.01)

Rather than avoiding these medications out of concern for worsening gastrointestinal disease, providers may feel more comfortable incorporating them into coordinated care, Dr

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(2019) suggests that minimizing ultra-processed foods, which are engineered to be hyperpalatable and may dysregulate appetite signaling, can reduce food preoccupation over time and lead to spontaneous reduction in calorie intake
Diabetes Care 34 , 771778 (2011)