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Gut 65 , 702711 (2016)

The STEP (Semaglutide Treatment Effect in People with obesity) trials, which included over 4,500 participants, showed that semaglutide 2.4 mg weekly resulted in mean weight loss of 12.4% to 15.3% of initial body weight over 68 weeks, compared to 2.4% to 3.2% with placebo

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The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity
