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While semaglutide costs 2-3 times more than Contrave, it produces roughly double the weight loss results in clinical trials

Statistics from the phase 3 SURMOUNT study, which recruited over 5,000 adults globally, demonstrated a pronounced reduction in body weight in the tirzepatide-treated group compared to placebo (NCT04184622)

priority review is 6 months, possible given unmet need

Increase the dose gradually as prescribed, eat smaller meals, avoid greasy foods, eat slowly and stay well hydrated

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In Phase 2 studies, patients lost up to 24.2% of body weight , compared to around 15% with Semaglutide, thanks to Retatrutides triple action on GLP-1, GIP, and glucagon receptors