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Symptoms include fatigue, muscle cramps, difficulty sleeping, and irritability

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The results, by dose: For context: in the equivalent Phase 2 trials, semaglutide produced about 14.9% weight loss at the highest dose, and tirzepatide produced about 20.9%

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23 Adverse reactions and tolerability: The DPP-4 inhibitor class of medications is generally very well tolerated, although post-marketing reports have described serious adverse events (see Warnings and precautions section)