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Common local reactions include: Some patients report less nausea when injecting in the thigh compared to the abdomen

All of the solutions were freshly prepared immediately before synthesis as stock solutions in DMF: Fmoc-protected amino acid (0.2 M), HCTU (0.5 M), DIPEA (1.0 M) and piperidine (20% v/v)

Semin Ophthalmol

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GLP-1 drugs, such as the blockbuster medication Ozempic (semaglutide) are now widely used in the treatment of obesity as well as T2D, offering reduced cardiovascular and renal morbidity to these patients

As noted, the sequence similarity within the glucagon superfamily of peptides and the structural similarity within the secretin receptor family served as the molecular basis for engineering chimeric peptides with agonism at multiple receptors and with sizes comparable to the native peptides