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doi:10.1097/fbp.0000000000000818 16.Garvey WT, Blher M, Osorto Contreras CK, et al

Fixed-dose combinations could optimize outcomes, particularly for patients with advanced disease or those unresponsive to monotherapy

However, their exorbitant costs and disproportionate accessibility highlight critical inequities, as higher-income individuals are far more likely to benefit

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The combined effects of decreased BA synthesis and an altered BA pool decrease the activities of FXR, TGR5, and VDR, which subsequently induce or promote inflammatory responses, thereby exacerbating the progression of gout

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