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How semaglutide works the mechanism behind the results Semaglutide is a GLP-1 receptor agonist

Since July 2024, Wegovy is also licensed by the MHRA to reduce the risk of serious cardiovascular events (heart attack, stroke) in adults with established cardiovascular disease and a body mass index (BMI) of 27 or above

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Safety and Tolerability in Early AOM Use The safety profile of anti-obesity medications (AOMs) requires careful consideration when implementing early intervention strategies for GLP-1 non-responders

However, clinical trials and real-world evidence consistently show that weight reduction with GLP-1RAs is accompanied by decrease in lean body mass, raising concern in patients already predisposed to muscle wasting and underscoring the need for integrated management strategies