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Optimal formulation selection depends on: Individual medical history and any contraindications to specific routes Personal comfort level with injections versus daily oral medication routine Lifestyle factors including travel frequency, work schedule, and daily routine Storage and refrigeration capabilities Cost considerations (both formulations similarly priced through Join Josie) Healthcare provider recommendation based on specific clinical circumstances and patient preferences Compounded GLP-1 Formulation Selection Disclaimer: The choice between injectable and oral compounded GLP-1 formulations should be made in consultation with healthcare provider during medical evaluation

Microdosing, which involves starting with significantly lower doses (0.1mg to 0.25mg), aims to mitigate these adverse effects, making the therapy more tolerable for a broader range of patients

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27 A recent phase II study of cilofexor given at doses of 30/day and 100 mg/day compared with placebo in 140 noncirrhotic NASH patients for 24 weeks showed a significant reduction in hepatic steatosis measured by magnetic resonance imaging-proton density fat fraction and a reduction in serum gamma-glutamyltransferase