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Researchers who have plateaued on dual agonists are exploring whether the switch from tirzepatide to retatrutide provides another level of receptor novelty and metabolic activation
Disclosures Alan Kaplan has conflicts in being either a member of an advisory board or speakers bureau of the following companies: Astra Zeneca, Behring, Boerhinger Ingelheim, Cipla, Covis, Eiasi, GSK, Merck Frosst, Novartis, Novo Nordisk, Pfizer, Sanofi Genzyme, Teva, Trudel, Valeo

4 Gastrointestinal side effects are common but can be managed

These numbers are important because they represent the maximum approved dose, which is what 50 units approximates at 5 mg/mL concentration

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1%), and unique clinical benefits
