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Furthermore, Ex4 treatment of isolated mouse cardiomyocytes increases the phosphorylation of AKT and ERK (105) and has positive effects on cardiomyocytes growth and survival (106)

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However, the evidence in humans remains preliminary and inconclusive, and neither EFSA nor the FSA has issued guidance restricting their use on this basis

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all patients should titrate to 1.2 mg after the first week to receive therapeutic levels for maximum antiglycemic effect (14)

Many of these side effects are a direct result of its mechanism of action, and patients are not advised to initiate on a high dose of Ozempic