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These include a relative or absolute increase in glucagon secretion from alpha cells of the pancreas, elevated serum free fatty-acid concentrations, an impaired incretin effect (e.g., decreased secretion of glucagon-like peptide-1 [GLP-1]), enhanced renal reabsorption of glucose, and dysregulation of appetite control via decreased neurotransmitter response in the brain

This class of drugs has been used for almost two decades to treat diabetes, although it is possible new side effects will become evident with more users and newer drugs

Gastrointestinal symptoms including nausea, vomiting, and diarrhea are most common, particularly during dose escalation

Participants were patients 18 years and older who had IIH

Pressley JC, Louis ED, Tang MX, Cote L, Cohen PD, Glied S, et al

doi: 10.1155/2022/1861940 43 SimRHernndezC