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Description
It is a mix of behavior and biology, but I would say it leans heavily toward biology. When you lose weight, the body employs a number of defense mechanisms

Kumari S, Anderson L, Farmer S, Mehta SL, Li PA

GLP-1 is primarily produced by enteroendocrine L-cells that are dispersed throughout the small and large intestines

As a result, nausea and fullness are most pronounced during treatment initiation or dose escalation

Indeed, ICC-IMs are known to play a key role in the initiation and coordination of GI motor activity (Dickens et al., 2001)

FDA prescribing information Wegovy (semaglutide) Most common adverse reactions for semaglutide 2.4 mg including nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, dyspepsia, and injection-site reactions
