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Classic agonists like liraglutide, semaglutide, and dulaglutide mimic the natural signal but keep it on far longer

Adults with biopsy-proven MASH and fibrosis stage F1F2F3, with or without type 2 diabetes, and with MRI-PDFF 8% at screening are randomised 1:1:1:1 to efocipegtrutide 2, 4, and 6 mg once-weekly subcutaneously or placebo for 52 weeks (estimated enrolment: N = 240)

10.2147/PPA.S82866

3,4 This specific configuration is believed to generate a synergistic effect that exceeds the efficacy of merely combining two separate agents

The contracts are worth an estimated $4 billion