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Thus, strategies aimed at promoting WAT browning may have great potential to improve metabolism and treat obesity, due to the ability of brown adipose tissue (BAT) to dissipate energy through thermogenesis [6]

The United States remains the reference market for the category

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For example, investigators found that orexigenic effects of systemically administered ghrelin (also known as the hunger hormone) were abolished in CB 1 receptor knockout mice 40 , and pharmacological blockade of the CB 1 receptor, via rimonabant administration, attenuated ghrelin-induced activation of the mesolimbic dopamine system a key pathway involved in reward processing 41

In summary, these data suggest one of neuroprotective effects of GLP-1R agonists is inhibiting neuronal apoptosis