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Weight loss is common with GLP-1 agonists, but to me, that side effect is much less important than the beneficial effects on heart disease and overall mortality that the medicine can provide

This paper is cited extensively across subsequent reviews including Paschou 2025 and Ridha 2024 as the underlying primary evidence for the proposed cellular mechanism
In clinical trials, some participants experienced improvements in their blood sugar levels within the first few weeks of taking tirzepatide

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64 Real-world data show relatively high rates of discontinuation

Source of the API All NDT drugs use porcine-derived desiccated thyroid powderThyroid USPas the active pharmaceutical ingredient (API)
