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Tier 2 - plausible but unproven The evidence for cardiovascular and kidney benefits are one layer down

Each modality targets different aspects of the gut-brain axis, highlighting the interconnectedness of gut health, metabolic regulation, and appetite control

Sodium-glucose cotransporter 2 inhibition for the prevention of cardiovascular events in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

doi: 10.1055/s-0041-1729945

Then, we summarize clinical data from postmarketting surveillance, randomized controlled trials, and observational studies

Systematic searches were conducted in PubMed/MEDLINE, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov from database inception through 31 May 2025