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NLY01, a long-acting pegylated exenatide form failed to show efficacy in a 36-week phase 2 study despite good tolerability [58]

The RESTORE trial is ongoing, and longer-term data will be necessary to determine whether the observed reproductive benefits are sustained

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It impacts around 18% of people with diabetes and exhibits a higher prevalence than in those without diabetes

The GIP component appears to enhance insulin sensitivity in fat tissue, improve lipid metabolism, and potentially increase energy expenditure in ways that pure GLP-1 agonists cannot match