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During exercise, it is thought to act in a hormone-like manner to stimulate energy mobilization, leading to increased body temperature and highlighting its metabolic functions (102)

However, this activation can also trigger nausea

7 From evidence to decision: estimating net benefit under uncertainty Clinical decisions around GLP-1RAs in fertility-focused PCOS care are rarely binary

however, incidence of this adverse event in clinical trials was very low [21]

Together, these findings highlight the potential importance of disease context in modulating GLP1R expression and responsiveness

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