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Due to steric effects or planarity distortion, the 7-monosubstitution and 5- and 7-disubstitution of pyrazolopyrimidine tend to diminish inhibitory activity

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[DOI] [PubMed] [Google Scholar] 14.Drucker DJ, Habener JF, Holst JJ

FDA Label Update: October 2025 Plaintiffs argue these risks weren't adequately communicated