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Dose reduction was required in 12.5% of patients, mostly owing to gastrointestinal symptoms, and discontinuation for any reason occurred in 5.5%
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Whilst all GLP-1RAs use has increased, the largest change was seen in patients using tirzepatide and semaglutide ([figure 1B][1])

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The 5-year compound annual growth rate for this group of medicines was 36% compared with 2% for the traditional diabetes therapies
