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For example, if one population activated by factor X projects specifically to the amygdala but another activated by factor Y to the VTA, it would be possible to achieve more precise and selective VTA GLP-1R activation by simply applying factor Y

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Using propensity matching between the exposure and comparator groups, the authors found that patients exposed to a GLP-1RA had a greater reduction in AUDIT-C scores than unexposed controls, as well as those exposed to DPP-4Is, reflecting a greater reduction in alcohol consumption