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In summary, this study proposes an innovative therapeutic strategy that not only provides novel insights into the clinical potential and pharmacological mechanisms of GLP-1RAs in RA but also establishes a new cartilage-protective insight that challenges the prevailing synovium-centric approach to RA therapy

Tirzepatide is a drug that mimics the action of two natural hormones in the body

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This difference explains why the trial will likely be terminated early, and a more objective background risk estimation needs to be performed (if available) compared to heterogeneous prevalence studies

In non-comparative clinical trials in patients with ALL, the rates of grade 3 CRS were 2.4% with obe-cel, 26% with Tecartus, and 48% with Kymriah