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Biochemical and Biophysical Research Communications Endogenous GLP-1 acts on paraventricular nucleus to suppress feeding : Projection from nucleus tractus solitarius and activation of corticotropin-releasing hormone, nesfatin-1 and oxytocin neurons

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Orlistat in the long-term treatment of obesity in primary care settings

This means the final product is not reviewed for safety or efficacy the way commercial drugs are

No controlled pharmacokinetic study exists, but the STEP-1 trial (N=1,961) excluded heavy alcohol users, so safety data in this population is limited [22]