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[55] demonstrated that Cap exhibits anti-obesity effects by enhancing the mRNA expression of uncoupling protein 1 (UCP1) in WAT and upregulating proteins associated with thermogenesis, lipid metabolism, and energy transduction

On August 7, the Partnership for Safe Medicines and ADAP Advocacy Association filed a complaint asking the New York State Board of Pharmacy to take regulatory action against a pharmacy that allegedly sold counterfeit HIV medicine to a Queens, New York patient

These are well-documented in clinical trials and prescribing information for GLP-1 medications

Due to risks for decreased bioavailability of birth control pills, the manufacturer of Mounjaro (tirzepatide) recommends that patients either use barrier contraception for four weeks after initiation or dosage increase or switch to a non-oral contraceptive

PlexusDx Precision Peptide Genetic Test identifies variants in FTO, MC4R, and other metabolic genes that influence thermogenesis and body-temperature regulation during weight loss

Key Findings: Large human studies across multiple countries have not found increased thyroid cancer rates in GLP-1 users The FDA warning applies to medullary thyroid carcinoma (MTC)only 3-4% of all thyroid cancers The warning exists because rodents developed C-cell tumors, but humans and rodents differ biologically Some studies show associations, but these are explained by detection bias (more monitoring = finding pre-existing nodules) The Clayman Thyroid Center (2,000+ thyroid cancer patients/year) has not seen an MTC pattern linked to GLP-1 use (or for that matter any other thyroid malignancy) Clinical Recommendations: Patients with MTC history or MEN2 should not take GLP-1 receptor agonists Patients with common thyroid cancers (papillary, follicular, Hrthle cell) should not assume GLP-1 caused them or will have an effect upon them Decisions should be individualized, weighing metabolic benefits against theoretical concerns GLP-1 therapy does not require additional thyroid monitoring Quick Reference for Clinicians Understanding the Question What Medications Are We Discussing