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For context, semaglutide and tirzepatide do not produce dysesthesia at clinically significant rates, though a recent paper in PMC examined allodynia and dysesthesia reports across GLP-1 medications more broadly

Crit Rev Oncol Hematol 2022;176:103749.ArticlePubMed 42

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If you are prescribed a GLP-1 medication and exhibit any of the following symptoms, you should contact your provider immediately: A lump or swelling in the neck Hoarseness Difficulty swallowing Shortness of breath Severe abdominal pain Before taking GLP-1 medications, you should also discuss the following with your provider: Allergies : Inform your doctor and pharmacist of any allergies you have to semaglutide (including under brand names Ozempic, Rybelsus, Wegovy) or similar medications such as tirzepatide (Mounjaro, Zepbound), dulaglutide (Trulicity), exenatide (Bydureon BCise, Byetta), liraglutide (Saxenda, Victoza, or in Xultophy) and lixisenatide (Adlyxin, or in Soliqua)

Step four: starting retatrutide After the full washout period, you begin retatrutide