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For diabetic retinopathy, GLP-1RAs are associated with the early worsening phenomenon linked to rapid glycemic control, a signal not typically observed with SGLT2 inhibitors, which generally show a neutral or modestly protective effect

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Patients experiencing itching should consider the timing of symptom onset relative to injection, the location and severity of itching, and any accompanying symptoms such as rash, swelling, or difficulty breathing

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