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41 Overall, oral semaglutide, the single oral GLP1-RA agent, seems to be an effective and safe hypoglycemic agent in T2DM and might be considered as a promising future alternative option and an add-on therapy to further improve Hb1Ac and reduce weight, while securing a low risk of hypoglycaemic episodes

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Diabetes 53:32673273 Sloop KW, Cao JX, Siesky AM et al (2004) Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors