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Alternating between semaglutide and tirzepatide on a weekly or monthly basis may prevent the receptor desensitization that contributes to stalls on either medication alone

Liver function also contributes to drug metabolism, though semaglutide relies more heavily on kidney filtration than hepatic breakdown

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But its likely due to compounds in coffee called polyphenols, not the caffeine specifically

Comparison of the effects of glucagon-like peptide receptor agonists and sodium-glucose cotransporter 2 inhibitors for prevention of major adverse cardiovascular and renal outcomes in type 2 diabetes mellitus