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Diabetes Care 41(9):19811990

HCPs must be aware that comprehensive dietary education, flexibility during the dose-escalation phase and appropriate symptomatic treatment of persistent GI AEs are factors of paramount importance to minimize the GI side effects associated with GLP-1 RA use

101 Moreover, due to their long half-life, a washout period of at least 2 months should be taken before trying to conceive, which is stated in the semaglutide approval package inserts

Restoring gut-immune-brain homeostasis

While not an absolute contraindication, severe, uncontrolled GERD can be aggravated by the gastric-slowing effects of GLP-1 medications