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Retatrutide is an investigational triple agonist (GLP-1/GIP/glucagon) that has shown even greater weight loss than tirzepatide in early trials (up to 24% body weight reduction)

The SURMOUNT-1 trial protocol allowed one dose de-escalation for intolerable side effects, which underscores that slower titration is acceptable and sometimes preferred

Modified escalation for skin-sensitive individuals If you have a history of skin sensitivity, neuropathic conditions, or have already experienced sensitivity at lower doses, consider a modified approach

Disclaimer: This information is for educational purposes only and is not intended as medical advice

This has cascading effects

Slows gastric emptying