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[12] One study found that those with an out-of-whack sleep schedule (due to factors like night shift work or insomnia) tend to have a low GLP-1 response and a high risk of insulin resistance and obesity

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More commonly, these symptoms relate to inadequate calorie intake, dehydration, or other medication side effects

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While the weight loss associated with semaglutide is likely one factor in the reduction of cardiac events, the studys authors saw the number of events go down even before maximum weight loss occurr ed

The strongest predictor of response was residual body fat percentage at time of switch