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1.7%, p = 0.08)

Research in animals shows negative effects on reproduction with GLP-1 drugs

The robust triglyceride reduction seen at higher retatrutide doses is attributed to the glucagon receptor pathways direct stimulation of hepatic fat oxidation, which reduces hepatic VLDL secretion and subsequently lowers circulating triglyceride concentrations

The same finding had been reported by a prior larger meta-analysis (6,914 patients with overweight or obesity and T2DM) over 8 studies 184,185,189,190,191,192,193,194 , but only when the largest study that also included non-diabetic participants 193 was excluded in a sensitivity analysis 195

doi: 10.1016/s0014-5793(02)03492-0

This configuration imparts remarkable stability, protecting the peptide from degradation and enhancing its bioactivity