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If a medicine affects how the body absorbs drugs through the stomach, doctors should consider how that might impact the effectiveness of oral birth control pills
This risk was first flagged for all versions of Lupron Depot by the FDA in 2023 and was included in its watch list based on reports received through the FDA Adverse Events Reporting System

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the subject recovered after 2 days)

Perceived effort is a more useful guide, so aim for the level where you can still talk in short sentences between breaths

Plan the Transition Before You Begin It Successful transitions are planned months in advance, not decided suddenly
