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This pattern may indicate suboptimal dosing or individual pharmacokinetic variation

The key finding: GLP-1 receptor agonists significantly reduce levels of Cyp2e1 a liver enzyme that normally breaks down alcohol into acetaldehyde (the toxic compound responsible for much of alcohol's liver damage)

Tirzepatide at the doses of 10 and 15 mg was noninferior to insulin degludec (primary endpoint) and all three doses of tirzepatide demonstrated superiority in comparison to insulin degludec regarding the change in HbA1c

Eloralintide, a selective amylin receptor agonist for the treatment of obesity: a 48-week phase 2, multicentre, double-blind, randomised, placebo-controlled trial